Novel approach to data analysis in cocaine-conditioned place preference
نویسندگان
چکیده
منابع مشابه
Intravenous cocaine priming reinstates cocaine-induced conditioned place preference
Separate groups of rats underwent an unbiased conditioned place preference (CPP) procedure involving alternate pairings of distinct environments with intravenous (IV) injections of cocaine (.75 mg/kg) or saline immediately or 15 min after injection. A subsequent extinction phase consisted of exposure to both conditioning environments preceded by saline injection (Ext). Finally, an IV priming in...
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Metabotropic glutamate receptor 5 (mGluR5) null mutant (-/-) mice have been reported to totally lack the reinforcing or locomotor stimulating effects of cocaine. We tested mGluR5 -/and +/+ mice for their locomotor and conditioned placepreference response to cocaine. Unlike the previous finding, here we show that compared to mGluR5 +/+ mice, -/mice exhibit no difference in the locomotor response...
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Adviser: Shirzad Jenab, Ph.D. The development and maintenance of cocaine addiction and relapse after abstinence depend heavily on learned associations between environmental stimuli and the rewarding properties of the drug. Cocaine and other abused drugs activate intracellular signaling cascades throughout the mesocorticolimbic reward circuitry, leading to functional changes in brain structure. ...
متن کاملDelayed extinction and stronger reinstatement of cocaine conditioned place preference in adolescent rats, compared to adults.
Adolescence is a transitional period during development that is associated with a greater likelihood of addiction to drugs than any other age. One possibility for this observation is that learned associations between the rewarding experience of drugs and drug-related cues may produce greater motivational salience, and thus are more difficult to extinguish. Using an unbiased place-conditioning p...
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The use of a virtual reality environment (VRE) enables behavioral scientists to create different spatial contexts in which human participants behave freely, while still confined to the laboratory. In this article, VRE was used to study conditioned place preference (CPP) and aversion (CPA). In Experiment 1, half of the participants were asked to visit a house for two minutes with consonant music...
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ژورنال
عنوان ژورنال: Behavioural Pharmacology
سال: 2009
ISSN: 0955-8810
DOI: 10.1097/fbp.0b013e328333b266